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Palladium-Catalyzed Tandem Dehydrogenative [4 + 2] Annulation of Terminal Olefins with N-Sulfonyl Amides via C-H Activations

Manman Sun, Weida Chen, Xiangyu Xia, Guodong Shen, Yongmin Ma, Jianguo Yang, Hanfeng Ding and Zhiming Wang*

*Advanced Research Institute and Department of Chemistry, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, P. R. China, Email: zhimingtzc.edu.cn

M. Sun, W. Chen, X. Xia, G. Shen, Y. Ma, J. Yang, H. Ding, Z. Wang, Org. Lett., 2020, 22, 3229-3233.

DOI: 10.1021/acs.orglett.0c01011


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Abstract

A palladium-catalyzed tandem dehydrogenative [4 + 2] annulation of terminal olefins with N-sulfonyl amides provides important heterocyclic compounds bearing a vinyl substituent with high E stereoselectivity in the presence of air as the terminal oxidant.


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Palladium-Catalyzed [4+2] Annulation of Aryl and Alkenyl Carboxamides with 1,3-Dienes via C-H Functionalization: Synthesis of 3,4-Dihydroisoquinolones and 5,6-Dihydropyridinones

M. Sun, J. Li, W. Chen, H. Wu, J. Yang, Z. Wang, Synthesis, 2020, 52, 1253-1265.


Key Words

palladium, [4+2] annulation, oxygen, carboxamides, dienes, C-H functionalization, 3,4-dihydroisoquinolones, 5,6-dihydropyridinones


ID: J54-Y2020