Palladium-Catalyzed Direct Oxidative C-H Activation/Annulation for Regioselective Construction of N-Acylindoles

Raju S. Thombal and Yong Rok Lee*

*School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea, Email: yrleeyu.ac.kr

R. S. Thombal, Y. R. Lee, Org. Lett., 2020, 22, 3397-3401.

DOI: 10.1021/acs.orglett.0c00877

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Abstract

A Pd(II)-catalyzed C(sp³)-H/C(sp²)-H coupling/annulation of anilides and α-dicarbonyl compounds provides diverse N-acyl indoles with high functional group tolerance and excellent regioselectivity.

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Key Words

indoles, potassium peroxydisulfate

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ID: J54-Y2020