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Electrochemical HI-mediated Intermolecular C-N Bond Formation to Synthesize Imidazoles from Aryl Ketones and Benzylamines

Zan Yang, Jiaqi Zhang, Liping Hu, An Li, Lijun Li, Kun Liu*, Tao Yang* and Congshan Zhou*

*College of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414006, China, Email: liukun328126.com, yangtaozcs126.com, zhoucongsh126.com

Z. Yang, J. Zhang, L. Hu, A. Li, L. Li, K. Liu, T. Yang, C. Zhou, J. Org. Chem., 2020, 85, 5815-5824.

DOI: 10.1021/acs.joc.0c00316 (free Supporting Information)


Abstract

An efficient electrochemical oxidative tandem cyclization of aryl ketones and benzylamines provides 1,2,4-trisubstituted-(1H)-imidazoles in very good yields under metal- and oxidant-free conditions. This direct C-N bond formation strategy offers a broad functional group tolerance.


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Key Words

imidazoles, electrochemistry


ID: J42-Y2020