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Synthesis of Linear α,β-Unsaturated Amides from Isocyanates and Alkenylaluminum Reagents

Bo Chen, Xiao-Feng Wu*

*Leibniz-Institut für Katalyse e.V. an der Universität Rostock, ­Albert-Einstein-Straße 29a 18059 Rostock, Germany, Email: Xiao-feng.wucatalysis.de

B. Chen, X.-F. Wu, Synlett, 2020, 31, 788-792.

DOI: 10.1055/s-0037-1610753 (free Supporting Information)


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Abstract

A direct coupling of isocyanates with alkenylaluminum reagents provides linear α,β-unsaturated amides in very good yields at room temperature in the absence of any catalyst or additive. The reaction offers good functional-group tolerance.

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Key Words

enamides, alkenylaluminum reagents, isocyanates, coupling reaction, catalyst-free


ID: J72-Y2020