Synthesis of Linear α,β-Unsaturated Amides from Isocyanates and Alkenylaluminum Reagents
Bo Chen, Xiao-Feng Wu*
*Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a 18059 Rostock, Germany,
Email: Xiao-feng.wu
catalysis.de
B. Chen, X.-F. Wu, Synlett, 2020, 31, 788-792.
DOI: 10.1055/s-0037-1610753
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Abstract
A direct coupling of isocyanates with alkenylaluminum reagents provides linear α,β-unsaturated amides in very good yields at room temperature in the absence of any catalyst or additive. The reaction offers good functional-group tolerance.
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Key Words
enamides, alkenylaluminum reagents, isocyanates, coupling reaction, catalyst-free
ID: J72-Y2020
