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Titanocene-Catalyzed Reductive Domino Epoxide Ring Opening/Defluorinative Cross-Coupling Reaction

Zhiyang Lin, Yun Lan and Chuan Wang*

*Center for Excellence in Molecular Synthesis of CAS, Hefei, Anhui 230026, P. R. China, Email:

Z. Lin, Y. Lan, C. Wang, Org. Lett., 2020, 22, 3509-3514.

DOI: 10.1021/acs.orglett.0c00960

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A titanocene-catalyzed reductive domino reaction provides gem-difluorobishomoallylic alcohols starting from trifluoromethyl-substituted alkenes and epoxides. Furthermore, diverse 6-fluoro-3,4-dihydro-2H-pyrans have been prepared through derivatization of the cross-coupling products in a single step.

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Key Words


ID: J54-Y2020