Organic Chemistry Portal



Benzylic Hydroperoxidation via Visible-Light-Induced Csp3-H Activation

Joan Inoa, Mansi Patel, Grecia Dominici, Reem Eldabagh, Anjali Patel, John Lee and Yalan Xing*

*Department of Chemistry, William Paterson University of New Jersey, 300 Pompton Road, Wayne, New Jersey 07470, United States, Email:

J. Inoa, M. Patel, G. Dominici, R. Eldabagh, A. Patel, J. Lee, Y. Xing, J. Org. Chem., 2020, 85, 6181-6187.

DOI: 10.1021/acs.joc.0c00385

see article for more reactions


Eosin Y catalyzes a highly efficient benzylic hydroperoxidation using an energy-economical light source (blue LED), and a sustainable oxidant (molecular oxygen). Primary, secondary, and tertiary hydroperoxides as well as silyl, benzyl, and acyl peroxides were successfully prepared with good yields and excellent functional group compatibility.

see article for more examples

Key Words

hydroperoxidation, oxygen, photochemistry

ID: J42-Y2020