O-Monoacyltartaric Acid/(Thio)urea Cooperative Organocatalysis for Enantioselective Conjugate Addition of Boronic Acid
Takuto Yoshimitsu, Yukinobu Kuboyama, Sari Nishiguchi, Makoto Nakajima and Masaharu Sugiura*
*Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan,
Email: msugiura
ph.sojo-u.ac.jp
T. Yoshimitsu, Y. Kuboyama, S. Nishiguchi, M. Nakajima, M. Sugiura, Org. Lett., 2020, 22, 3780-3784.
DOI: 10.1021/acs.orglett.0c00981
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Abstract
A (thio)urea cocatalyst accelerates O-monoacyltartaric acid (MAT)-catalyzed enantioselective conjugate additions of boronic acid to unsaturated ketone.
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Key Words
1,4-addition, vinylation, organocatalysis
ID: J54-Y2020
