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Synthesis of Indolizine Derivatives Triggered by the Oxidative Addition of Aroyl Chloride to Pd(0) Complex

Yahui Li, Wei Xiong, Zhifeng Zhang and Tongyu Xu*

*College of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R. China, Email:

Y. Li, W. Xiong, Z. Zhang, T. Xu, J. Org. Chem., 2020, 85, 6392-6399.

DOI: 10.1021/acs.joc.0c00161

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A Pd-catalyzed reaction of propargylic pyridines with aroyl chlorides provides indolizine derivatives in very good yields via a 5-endo-dig cyclization initiated by an in situ formed acylpalladium species. This transformation successfully occurred in the presence of an N-nucleophilic moiety and acid chlorides.

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Key Words


ID: J42-Y2020