Organic Chemistry Portal



K2S as Sulfur Source and DMSO as Carbon Source for the Synthesis of 2-Unsubstituted Benzothiazoles

Xiaoming Zhu*, Fuxing Zhang, Daizhi Kuang, Guobo Deng, Yuan Yang, Jiangxi Yu* and Yun Liang*

*Hengyang Normal University, Hengyang, Hunan 421008; Hunan Normal University, Changsha, Hunan 410081, China, Email:,,

X. Zhu, F. Zhang, D. Kuang, G. Deng, Y. Yang, J. Yu, Y. Liang, Org. Lett., 2020, 22, 3789-3793.

DOI: 10.1021/acs.orglett.0c00994

see article for more reactions


A three-component reaction of o-iodoanilines or electron-rich aromatic amines with K2S and DMSO provides 2-unsubstituted benzothiazoles in good isolated yields with good functional group tolerance. A similar reaction of o-phenylenediamines provided 2-unsubstituted benzimidazoles without K2S. DMSO plays three vital roles: carbon source, solvent, and oxidant.

see article for more examples

Key Words

benzothiazoles, benzimidazoles, multicomponent reactions

ID: J54-Y2020