Self-Catalyzed Rapid Synthesis of N-Acylated/N-Formylated α-Aminoketones and N-Hydroxymethylated Formamides from 3-Aryl-2H-Azirines and 2-Me/Ph-3-Aryl-2H-Azirines
Aramita De, Sougata Santra, Grigory V. Zyryanov and Adinath Majee*
*Department of Chemistry, Visva-Bharati (A Central University), Santiniketan 731235, India,
Email: adinath.majee
visva-bharati.ac.in
A. De, S. Santra, G. V. Zyryanov, A. Majee, Org. Lett., 2020, 22, 3875-3878.
DOI: 10.1021/acs.orglett.0c01206
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Abstract
A rapid and effective reaction of 3-aryl-2H-azirines and highly substituted 2-Me/Ph-3-aryl-2H-azirines with various carboxylic acids provides N-acylated α-aminoketone derivatives under ambient air within 10 min at room temperature.
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proposed mechanism
Key Words
ID: J54-Y2020
