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Self-Catalyzed Rapid Synthesis of N-Acylated/N-Formylated α-Aminoketones and N-Hydroxymethylated Formamides from 3-Aryl-2H-Azirines and 2-Me/Ph-3-Aryl-2H-Azirines

Aramita De, Sougata Santra, Grigory V. Zyryanov and Adinath Majee*

*Department of Chemistry, Visva-Bharati (A Central University), Santiniketan 731235, India, Email:

A. De, S. Santra, G. V. Zyryanov, A. Majee, Org. Lett., 2020, 22, 3875-3878.

DOI: 10.1021/acs.orglett.0c01206

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A rapid and effective reaction of 3-aryl-2H-azirines and highly substituted 2-Me/Ph-3-aryl-2H-azirines with various carboxylic acids provides N-acylated α-aminoketone derivatives under ambient air within 10 min at room temperature.

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proposed mechanism

Key Words

α-amino ketones

ID: J54-Y2020