Organic Chemistry Portal



Anodic Oxidation of Dithiane Carboxylic Acids: A Rapid and Mild Way to Access Functionalized Orthoesters

Anthony D. Garcia, Matthew C. Leech, Alessia Petti, Camille Denis, Iain C. A. Goodall, Adrian P. Dobbs and Kevin Lam*

*School of Science, University of Greenwich, Chatham, Kent, Chatham Maritime ME4 4TB, United Kingdom, Email:

A. D. Garcia, M. C. Leech, A. Petti, C. Denis, I. C. A. Goodall, A. P. Dobbs, K. Lam, Org. Lett., 2020, 22, 3875-3878.

DOI: 10.1021/acs.orglett.0c01324

see article for more reactions


A wide variety of functionalized orthoesters can be prepared under mild and green electrochemical conditions from easily accessible dithiane derivatives.

see article for more examples

Key Words

ortho esters, 1,3-dithianes, electrochemistry

ID: J54-Y2020