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Palladium-Catalyzed Synthesis of N,N-Dimethylanilines via Buchwald-Hartwig Amination of (Hetero)aryl Triflates

Tobias Taeufer and Jola Pospech*

*Leibniz Institute for Catalysis at Rostock University, Albert-Einstein-Str. 29a, 18059 Rostock, Germany, Email:

T. Taeufer, J. Pospech, J. Org. Chem., 2020, 85, 7097-7111.

DOI: 10.1021/acs.joc.0c00491

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The palladium-catalyzed C-N bond formation between dimethylamines and aryl triflates proceeds in excellent yields, using an unsophisticated catalytic system, a mild base, and triflates as electrophiles, which are readily available from inexpensive phenols.

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Key Words

Buchwald-Hartwig Coupling, arylamines

ID: J42-Y2020