Palladium-Catalyzed Synthesis of N,N-Dimethylanilines via Buchwald-Hartwig Amination of (Hetero)aryl Triflates
Tobias Taeufer and Jola Pospech*
*Leibniz Institute for Catalysis at Rostock University, Albert-Einstein-Str. 29a, 18059 Rostock, Germany, Email: Jola.Pospechcatalysis.de
T. Taeufer, J. Pospech, J. Org. Chem., 2020, 85, 7097-7111.
DOI: 10.1021/acs.joc.0c00491 (free Supporting Information)
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The palladium-catalyzed C-N bond formation between dimethylamines and aryl triflates proceeds in excellent yields, using an unsophisticated catalytic system, a mild base, and triflates as electrophiles, which are readily available from inexpensive phenols.
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