Manganese-Catalyzed Regioselective Dehydrogenative C- versus N-Alkylation Enabled by a Solvent Switch: Experiment and Computation
Jannik C. Borghs, Viktoriia Zubar, Luis Miguel Azofra, Jan Sklyaruk and Magnus Rueping*
*KAUST Catalysis Center (KCC), KAUST, Thuwal 23955-6900, Saudi Arabia,
Email: magnus.rueping
kaust.edu.sa
J. C. Borghs, V. Zubar, L. M. Azofra, J. Sklyaruk, M. Rueping, Org. Lett., 2020, 22, 4222-4227.
DOI: 10.1021/acs.orglett.0c01270
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Abstract
In a regioselective dehydrogenative alkylation of indolines using readily available alcohols as the alkylating reagents, a single air- and moisture-stable manganese catalyst provides access to either C3- or N-alkylated indoles depending on the solvent used.
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Key Words
ID: J54-Y2020
