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Manganese-Catalyzed Regioselective Dehydrogenative C- versus N-Alkylation Enabled by a Solvent Switch: Experiment and Computation

Jannik C. Borghs, Viktoriia Zubar, Luis Miguel Azofra, Jan Sklyaruk and Magnus Rueping*

*KAUST Catalysis Center (KCC), KAUST, Thuwal 23955-6900, Saudi Arabia, Email:

J. C. Borghs, V. Zubar, L. M. Azofra, J. Sklyaruk, M. Rueping, Org. Lett., 2020, 22, 4222-4227.

DOI: 10.1021/acs.orglett.0c01270

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In a regioselective dehydrogenative alkylation of indolines using readily available alcohols as the alkylating reagents, a single air- and moisture-stable manganese catalyst provides access to either C3- or N-alkylated indoles depending on the solvent used.

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Key Words


ID: J54-Y2020