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Cascade Reactions to Substituted 1H-Pyrrole-3-carbonitriles via Ligand-Free Palladium(II)-Catalyzed C(sp)-C(sp2) Coupling

Zijuan Wang, Wenteng Chen, Haofan Luo, Chang He, Guolin Zhang*, Yongping Yu*

*Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, P. R. of China, Email:,

Z. Wang, W. Chen, H. Luo, C. He, G. Zhang, Y. Yu, Synthesis, 2020, 52, 1659-1665.

DOI: 10.1055/s-0039-1691731

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An efficient and simple palladium(II)-catalyzed cascade reaction of 2-(2-oxo-2-arylethyl)malononitriles with boronic acids provides substituted 1H-pyrrole-3-carbonitriles via C(sp)-C(sp2) coupling followed by intramolecular C-N bond formation.

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Key Words

C-C coupling, palladium, ligand-free, cascade reactions, pyrroles, substituted 1H-pyrrole-3-carbonitriles

ID: J66-Y2020