Three-Component, Interrupted Radical Heck/Allylic Substitution Cascade Involving Unactivated Alkyl Bromides
Huan-Ming Huang, Peter Bellotti, Philipp M. Pflüger, J. Luca Schwarz, Bastian Heidrich and Frank Glorius*
*Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster, Germany,
Email: glorius
uni-muenster.de
H.-M. Huang, P. Bellotti, P. M. Pfüger, J. L. Schwarz, B. Heidrich, F. Glorius, J. Am. Chem. Soc., 2020, 142, 10173-10183.
DOI: 10.1021/jacs.0c03239
see article for more reactions
Abstract
A modular, practical, and general palladium-catalyzed, radical three-component coupling enables selective 1,4-difunctionalization of unactivated 1,3-dienes, such as butadiene, by employing different commercially available nitrogen-, oxygen-, sulfur-, or carbon-based nucleophiles and unactivated alkyl bromides.
see article for more examples
Key Words
allyl sulfones, allyl amines, phthalimides, allylation, multicomponent reactions, photochemistry
ID: J48-Y2020
