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Dehydrative Allylation of α C(sp3)-H Bonds of Alkylamines with Allylic Alcohols

Yusuke Masuda, Misato Ito and Masahiro Murakami*

*Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto 615-8510, Japan, Email: murakamisbchem.kyoto-u.ac.jp

Y. Masuda, M. Ito, M. Murakami, Org. Lett., 2020, 22, 4467-4470.

DOI: 10.1021/acs.orglett.0c01464 (free Supporting Information)


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Abstract

A combination of a photoredox and a palladium catalyst catalyzes a dehydrative coupling reaction of alkyl amines with allylic alcohols to provide a range of homoallylic amines.

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Key Words

homoallylic amines, pyrrolidines, photochemistry


ID: J54-Y2020