Environmentally Friendly Nafion-Mediated Friedländer Quinoline Synthesis under Microwave Irradiation: Application to One-Pot Synthesis of Substituted Quinolinyl Chalcones
Chieh-Kai Chan, Chien-Yu Lai, Cheng-Chung Wang*
*Institute of Chemistry, Academia Sinica, Taipei 11529,
Taiwan, R.O.C., Email: wangcc
gate.sinica.edu.tw
C.-K. Chan, C.-Y. Lai, C.-C. Wang, Synthesis, 2020, 52, 1779-1794.
DOI: 10.1055/s-0039-1690088
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Abstract
Reusable Nafion NR50 material as a solid catalyst mediates an efficient and eco-friendly Friedländer quinoline synthesis of polysubstituted quinolines in very good yields from various 2-aminobenzophenones and mono- or dicarbonyl synthons in ethanol under microwave irradiation.
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Key Words
Friedländer reaction, Nafion catalyst, quinolines, chalcone, microwave synthesis
ID: J66-Y2020
