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Environmentally Friendly Nafion-Mediated Friedlšnder Quinoline Synthesis under Microwave Irradiation: Application to One-Pot Synthesis of Substituted Quinolinyl Chalcones

Chieh-Kai Chan, Chien-Yu Lai, Cheng-Chung Wang*

*Institute of Chemistry, Academia Sinica, Taipei 11529, Taiwan, R.O.C., Email:

C.-K. Chan, C.-Y. Lai, C.-C. Wang, Synthesis, 2020, 52, 1779-1794.

DOI: 10.1055/s-0039-1690088

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Reusable Nafion NR50 material as a solid catalyst mediates an efficient and eco-friendly Friedlšnder quinoline synthesis of polysubstituted quinolines in very good yields from various 2-aminobenzophenones and mono- or dicarbonyl synthons in ethanol under microwave irradiation.

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Key Words

Friedlšnder reaction, Nafion catalyst, quinolines, chalcone, microwave synthesis

ID: J66-Y2020