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tBuOK-Promoted Cyclization of Imines with Aryl Halides

Ya-Wei Li, Hong-Xing Zheng, Bo Yang, Xiang-Huan Shan, Jian-Ping Qu* and Yan-Biao Kang*

*Nanjing Tech University, Nanjing 211816; University of Science and Technology of China, Hefei, Anhui 230026, China, Email: ias_jpqunjtech.edu.cn, ybkangustc.edu.cn

Y.-W. Li, H.-X. Zheng, B. Yang, X.-H. Shan, J.-P. Qu, Y.-B. Kang, Org. Lett., 2020, 22, 4553-4556.

DOI: 10.1021/acs.orglett.0c01615 (free Supporting Information)


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Abstract

A radical coupling of 2-halotoluenes and imines followed by C-N bond construction enables a transition-metal-free indole synthesis. The standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant is required.

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Key Words

indoles


ID: J54-Y2020