Organic Chemistry Portal

Abstracts

Search:

tBuOK-Promoted Cyclization of Imines with Aryl Halides

Ya-Wei Li, Hong-Xing Zheng, Bo Yang, Xiang-Huan Shan, Jian-Ping Qu* and Yan-Biao Kang*

*Nanjing Tech University, Nanjing 211816; University of Science and Technology of China, Hefei, Anhui 230026, China, Email: ias_jpqunjtech.edu.cn, ybkangustc.edu.cn

Y.-W. Li, H.-X. Zheng, B. Yang, X.-H. Shan, J.-P. Qu, Y.-B. Kang, Org. Lett., 2020, 22, 4553-4556.

DOI: 10.1021/acs.orglett.0c01615


see article for more reactions

Abstract

A radical coupling of 2-halotoluenes and imines followed by C-N bond construction enables a transition-metal-free indole synthesis. The standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant is required.

see article for more examples



Key Words

indoles


ID: J54-Y2020