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IBX-Promoted Oxidative Cyclization of N-Hydroxyalkyl Enamines: A Metal-Free Approach toward 2,3-Disubstituted Pyrroles and Pyridines

Peng Gao*, Huai-Juan Chen, Zi-Jing Bai, Mi-Na Zhao, Desuo Yang, Juan Wang*, Ning Wang, Lele Du and Zheng-Hui Guan*

*University of Arts and Sciences, Baoji, Shaanxi 721013; Northwest University, Xi'an 710127, P. R. China, Email:,,

P. Gao, H.-J. Chen, Z.-J. Bai, M.-N. Zhao, D. Yang, J. Wang, N. Wang, L. Du, Z.-H. Guan, J. Org. Chem., 2020, 85, 7939-7951.

DOI: 10.1021/acs.joc.0c00625

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An iodoxybenzoic acid-mediated selected oxidative cyclization of N-hydroxyalkyl enamines provides a variety of 2,3-disubstituted pyrroles and pyridines in good selectivity. This metal-free method offers use of environmentally friendly reagents, broad substrate scope, mild reaction conditions, and high efficiency.

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Key Words

pyrroles, pyridines, IBX

ID: J42-Y2020