Lanthanum(III) Trifluoromethanesulfonate Catalyzed Direct Synthesis of Ureas from N-Benzyloxycarbonyl-, N-Allyloxycarbonyl-, and N-2,2,2-Trichloroethoxycarbonyl-Protected Amines

Tien Tan Bui, Hee-Kwon Kim*

*Department of Nuclear Medicine, Jeonbuk National University Medical School and Hospital, Jeonju, 54907, Republic of Korea, Email: hkkim717jbnu.ac.kr

T. T. Bui, H.-K. Kim, Synlett, 2020, 31, 997-1002.

DOI: 10.1055/s-0040-1707991

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Abstract

Lanthanum triflate catalyzes a direct conversion of N-benzyl­oxycarbonyl-, N-allyloxycarbonyl-, and N-trichloroethoxycarbonyl-protected amines into nonsymmetric ureas in high yields. A variety of protected aromatic and aliphatic carbamates reacted readily with various amines in the presence of lanthanum triflate to generate the desired ureas.

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Key Words

ureas, amines, lanthanum triflate catalysis, benzyloxycarbonyl amines, allyloxycarbonyl amines, trichloroethoxycarbonyl amines

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ID: J72-Y2020