Nickel-Catalyzed Cross-Electrophile Reductive Couplings of Neopentyl Bromides with Aryl Bromides
Soumik Biswas, Bo Qu*, Jean-Nicolas Desrosiers*, Younggi Choi, Nizar Haddad, Nathan K. Yee, Jinghua J. Song and Chris H. Senanayake
*Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, United States, Email: bo.quboehringer-ingelheim.com, nick.desrosierspfizer.com
S. Biswas, B. Qu, J.-N. Desrosiers, Y. Choi, N. Haddad, N. K. Yee, J. J. Song, C. H. Senanayake, J. Org. Chem., 2020, 85, 8214-8220.
see article for more reactions
5-Cyanoimidazole was identified as an inexpensive ligand for nickel-catalyzed cross-electrophile couplings for the preparation of various alkylated arene products with good yields. Furthermore, the scope of reductive couplings could be expanded to challenging substrates, such as sterically hindered neopentyl halides.
see article for more examples