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Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control

Benjamin N. Bhawal, Julia C. Reisenbauer, Christian Ehinger and Bill Morandi*

*ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093 Zürich, Switzerland, Email:

B. N. Bhawal, J. C. Reisenbauer, C. Ehinger, B. Morandi, J. Am. Chem. Soc., 2020, 142, 10914-10920.

DOI: 10.1021/jacs.0c03184


A practical reversible transfer hydrocyanation protocol exhibits high selectivity for the thermodynamically less favorable branched isomer based on the design of a novel type of HCN donor.

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ID: J48-Y2020