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Ruthenium(II)-Complex-Catalyzed Acceptorless Double Dehydrogenation of Primary Amines to Nitriles

Muthukumar Kannan, Senthilkumar Muthaiah*

*Department of Chemistry, National Institute of Technology Kurukshetra, Kurukshetra-136119, Haryana, India, Email:

M. Kannan, S. Muthaiah, Synlett, 2020, 31, 1073-1076.

DOI: 10.1055/s-0040-1708016


An in situ formed complex of commercially available dichloro(1,5-cyclooctadiene) ruthenium(II) and simple hexamethylenetetramine catalyzes acceptorless dehydrogenative oxidation of primary amines into nitriles in good yields. The synthetic protocol is highly selective and produces hydrogen as the sole byproduct.

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Key Words

ruthenium, amines, nitriles, dehydrogenation

ID: J72-Y2020