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Acetic Acid Promoted Direct Iodination of Terminal Alkynes with N-Iodosuccinimide: Efficient Preparation of 1-Iodoalkynes

Ming Yao*, Jingjing Zhang, Sen Yang, E Liu, Hangxing Xiong

*Jingchu University of Technology, Jingmen, 448000, P. R. of China, Email:

M. Yao, J. Zhang, S. Yang, E. Liu, H. Xiong, Synlett, 2020, 31, 1102-1106.

DOI: 10.1055/s-0040-1708002


Acetic acid activates N-iodosuccinimide for an efficient and highly chemoselective direct iodination of terminal alkynes under metal-free conditions. This convenient process tolerates a variety of terminal alkynes and provides the desired products in very good yields.

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Key Words

terminal alkynes, halogenation, 1-iodoalkynes, carboxylic acids, N-iodosuccinimide

ID: J72-Y2020