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Sulfur-Mediated Decarboxylative Coupling of 2-Nitrobenzyl Alcohols and Arylacetic Acids

Khang X. Nguyen, Duyen K. Nguyen, Phuc H. Pham, Ha V. Le, Tung T. Nguyen, Nam T. S. Phan*

*Department of Chemical Engineering, HCMC University of Technology, VNU-HCM, 268 Ly Thuong Kiet, District 10, Ho Chi Minh City, Vietnam, Email:

K. X. Nguyen, D. K. Nguyen, P. H. Pham, H. V. Le, T. T. Nguyen, N. T. S. Phan, Synlett, 2020, 31, 1112-1116.

DOI: 10.1055/s-0040-1707113

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The condensation of 2-nitrobenzyl alcohols with arylacetic acids provides substituted quinazolines under mild conditions in the presence of urea as a nitrogen source, elemental sulfur as a promoter, DABCO as a base, and DMSO as a solvent. The reaction tolerates functionalities such as chloro, fluoro, trifluoromethyl, thienyl, and indolyl groups.

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Key Words

quinazolines, nitrobenzyl alcohols, arylacetic acids, sulfur, cyclocondensation, decarboxylation

ID: J72-Y2020