Ir-Catalyzed Reversible Acceptorless Dehydrogenation/Hydrogenation of N-Substituted and Unsubstituted Heterocycles Enabled by a Polymer-Cross-Linking Bisphosphine

Deliang Zhang, Tomohiro Iwai* and Masaya Sawamura*

*Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan, Email: iwai-tsci.hokudai.ac.jp, sawamurasci.hokudai.ac.jp

D. Zhang, T. Iwai, M. Sawamura, Org. Lett., 2020, 22, 5240-5245.

DOI: 10.1021/acs.orglett.0c01874

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Abstract

The polystyrene-cross-linking bisphosphine ligand PS-DPPBz was effective for the Ir-catalyzed reversible acceptorless dehydrogenation/hydrogenation of N-heterocycles. Notably, this protocol is applicable to the dehydrogenation of a broad range of indoline derivatives.

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PS-DPPBz

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Key Words

indoles

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ID: J54-Y2020