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Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles

Denis Drikermann, Valerie Kerndl, Helmar Görls, Ivan Vilotijevic*

*Friedrich-Schiller-University Jena, Institute of Organic and Macromolecular Chemistry, Humboldtstraße 10, 07743 Jena, Germany, Email:

D. Drikermann, V. Kerndl, H. Görls, I. Vilotijevic, Synlett, 2020, 31, 1158-1162.

DOI: 10.1055/s-0040-1707111

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Vinyldiazo compounds undergo a thermal electrocyclization to form pyrazoles in good yields. These catalyst-free reactions are operationally simple, use readily available starting materials, and enable the synthesis of mono-, di- and tri-substituted pyrazoles.

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Key Words

pyrazoles, vinyldiazoacetates, vinyldiazo compounds, cyclization, electrocyclization

ID: J72-Y2020