Potassium Periodate Mediated Oxidative Cyclodesulfurization toward Benzofused Nitrogen Heterocycles
Chuthamat Duangkamol, Wong Phakhodee, Mookda Pattarawarapan*
*Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand,
Email: Mookdap55
gmail.com
C. Duangkamol, W. Phakhodee, M. Pattarawarapan, Synthesis, 2020, 52, 1981-1990.
DOI: 10.1055/s-0039-1690855
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Abstract
The reaction of isothiocyanates with ortho-substituted anilines bearing N,N-, N,O-, and N,S-bis-nucleophiles, followed by an intramolecular, potassium periodate mediated oxidative cyclodesulfurization of the in situ generated monothioureas provides substituted 2-aminobenzazole derivatives in very good yields.
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Key Words
cyclization, oxidation, benzimidazoles, benzoxazoles, benzothiazoles, quinazolinones, potassium periodate
ID: J66-Y2020
