Tandem Photoredox and Copper-Catalyzed Decarboxylative C(sp³)-N Coupling of Anilines and Imines Using an Organic Photocatalyst

Guido Barzanò, Runze Mao, Marion Garreau, Jerome Waser and Xile Hu*

*Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fedérale dé Lausanne (EPFL), ISIC-LSCI, BCH 3305, Lausanne 1015, Switzerland, Email: xile.huepfl.ch

G. Barzanò, R. Mao, M. Garreau, J. Waser, X. Hu, Org. Lett., 2020, 22, 5412-5416.

DOI: 10.1021/acs.orglett.0c01769

---

see article for more reactions

Abstract

A catalytic amount of CuCl was used in combination with 4CzIPN as organic photoredox catalyst to effect decarboxylative C(sp³)-N coupling. The reaction provides a variety of alkyl amines from readily available alkyl carboxylic acids. The coupling worked with both anilines and imines as nitrogen sources.

see article for more examples

4CzIPN

---

---

Key Words

arylamines

---

ID: J54-Y2020