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Palladium-Catalyzed N-Acylation of Tertiary Amines by Carboxylic Acids: A Method for the Synthesis of Amides

Zhaohui Li, Long Liu, Kaiqiang Xu, Tianzeng Huang, Xinyi Li, Bin Song and Tieqiao Chen*

*Hainan Provincial Key Lab of Fine Chemicals, Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China, Email:

Z. Li, L. Liu, K. Xu, T. Huang, X. Li, B. Song, T. Chen, Org. Lett., 2020, 22, 5517-5521.

DOI: 10.1021/acs.orglett.0c01869

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A palladium-catalyzed N-acylation of tertiary amines by carboxylic acids produces the corresponding amides in very good yields via cleavage of a C-N bond. Both aromatic and aliphatic acids served well as the acylating reagents.

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Key Words


ID: J54-Y2020