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Catalytic Dealkylative Synthesis of Cyclic Carbamates and Ureas via Hydrogen Atom Transfer and Radical-Polar Crossover

Takuya Nagai, Nao Mimata, Yoshihiro Terada, Chikayoshi Sebe and Hiroki Shigehisa*

*Faculty of Pharmacy, Musashino University 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan, Email:

T. Nagai, N. Mimata, Y. Terada, C. Sebe, H. Shigehisa, Org. Lett., 2020, 22, 5522-5527.

DOI: 10.1021/acs.orglett.0c01872 (free Supporting Information)

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A functional-group-tolerant and scalable cobalt-catalyzed cyclization of alkenyl carbamates and alkenyl isoureas provides common five- and six-to-eight-membered cyclic carbamates and ureas via transition-metal hydrogen atom transfer and radical-polar crossover.

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Key Words

oxazolidinones, imidazolidinones

ID: J54-Y2020