Cobalt-Catalyzed Decarboxylative Methylation and Ethylation of Aliphatic N-(Acyloxy)phthalimides with Organoaluminum Reagents
Ze-Zhong Wang, Guang-Zu Wang, Bin Zhao, Rui Shang*, Yao Fu*
*Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. of China, Email: fuyaoustc.edu.cn, ruichem.s.u-tokyo.ac.jp
Z.-Z. Wang, G.-Z. Wang, B. Zhao, R. Shang, Y. Fu, Synlett, 2020, 31, 1221-1225.
DOI: 10.1055/s-0040-1707946 (free Supporting Information)
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A cobalt-catalyzed decarboxylative methylation of primary and secondary aliphatic redox-active esters with trimethylaluminum provides methylated products without redox fluctuation under mild conditions. The use of triethylaluminum enables a decarboxylative ethylation.
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