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Cobalt-Catalyzed Decarboxylative Methylation and Ethylation of Aliphatic N-(Acyloxy)phthalimides with Organoaluminum Reagents

Ze-Zhong Wang, Guang-Zu Wang, Bin Zhao, Rui Shang*, Yao Fu*

*Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. of China, Email: fuyaoustc.edu.cn, ruichem.s.u-tokyo.ac.jp

Z.-Z. Wang, G.-Z. Wang, B. Zhao, R. Shang, Y. Fu, Synlett, 2020, 31, 1221-1225.

DOI: 10.1055/s-0040-1707946 (free Supporting Information)



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Abstract

A cobalt-catalyzed decarboxylative methylation of primary and secondary aliphatic redox-active esters with trimethylaluminum provides methylated products without redox fluctuation under mild conditions. The use of triethylaluminum enables a decarboxylative ethylation.

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Key Words

cobalt catalysis, decarboxylation, alkylation, trimethylaluminum, redox-active esters


ID: J72-Y2020