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Copper-Catalyzed Coupling of Arylboronic Acids and Amines

Jon C. Antilla and Stephen L. Buchwald

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

J. C. Antilla, S. L. Buchwald, Org. Lett., 2001, 3, 2077-2079.

DOI: 10.1021/ol0160396

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Copper(II) acetate catalyzes a coupling of arylboronic acids and amines in the presence of 2,6-lutidine as base, and myristic acid as an additive. Functionalized aniline substrates provided diarylamine coupling products in good yield, whereas alkylamines gave N-alkyl anilines in moderate yield.

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Key Words

Chan-Lam coupling

ID: J54-Y2020