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Catalyst- and Solvent-Free Hydrophosphorylation of Ketones with Secondary Phosphine Oxides: Green Synthesis of Tertiary α-Hydroxyphosphine Oxides

Nina K. Gusarova, Nina I. Ivanova, Kseniya O. Khrapova, Pavel A. Volkov, Anton A. Telezhkin, Lyudmila I. Larina, Andrei V. Afonin, Dmitry V. Pavlov, Boris A. Trofimov*

*A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Str., 664033 Irkutsk, Russian Federation, Email: boris_trofimovirioch.irk.ru

N. K. Gusarova, N. I. Ivanova, K. O. Khrapova, P. A. Volkov, A. A. Telezhkin, L. I. Larina, A. V. Afonin, D. V. Pavlov, B. A. Trofimov, Synthesis, 2020, 52, 2224-2232.

DOI: 10.1055/s-0040-1707945 (free Supporting Information)


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Abstract

A catalyst- and solvent-free reaction between secondary phosphine oxides and aliphatic, aromatic and heteroaromatic ketones provides tertiary α-hydroxyphosphine oxides in excellent yield.

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Key Words

ketones, phosphine oxides, catalyst- and solvent-free addition, green chemistry, α-hydroxyphosphine oxides


ID: J66-Y2020