Copper-Catalyzed C-H Fluorination/Functionalization Sequence Enabling Benzylic C-H Cross Coupling with Diverse Nucleophiles
Aristidis Vasilopoulos, Dung L. Golden, Joshua A. Buss and Shannon S. Stahl*
*Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States,
Email: stahl
chem.wisc.edu
A. Vasilopoulos, D. L. Golden, J. A. Buss, S. S. Stahl, Org. Lett., 2020, 22, 5746-5748.
DOI: 10.1021/acs.orglett.0c02238
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Abstract
A Cu-catalyzed C-H fluorination with N-fluorobenzenesulfonimide (NFSI), followed by substitution of the resulting fluoride with various nucleophiles, enables a site-selective transformation of benzylic C-H bonds into diverse functional groups.
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Key Words
ID: J54-Y2020
