Asymmetric Ni-Catalyzed Radical Relayed Reductive Coupling

Xiaofeng Wei, Wei Shu, Andrés García-Domínguez, Estíbaliz Merino and Cristina Nevado*

*Department of Chemistry, University of Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland, Email: cristina.nevadochem.uzh.ch

X. Wei, W. Shu, A. García-Domínguez, E. Merino, C. Nevado, J. Am. Chem. Soc., 2020, 142, 13515-13522.

DOI: 10.1021/jacs.0c05254

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Abstract

A highly efficient asymmetric intermolecular Ni-catalyzed reductive dicarbofunctionalization of vinyl amides, vinyl boranes, or vinyl phosphonates with two distinct readily available electrophiles, namely, Csp²- and Csp³-halides, provides chiral products in a highly regio- and enantioselective manner.

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Key Words

benzylic amines, alkylation, multicomponent reactions, TDAE

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ID: J48-Y2020