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General Cu-Catalyzed Csp-S Coupling

Éric Godin, Jeffrey Santandrea, Antoine Caron and Shawn K. Collins*

*Département de Chimie, Université de Montréal, Complexe des Sciences, 1375 Avenue Thérèse-Lavoie-Roux, Montréal, Québec H2V 0B3, Canada, Email: shawn.collinsumontreal.ca

E. Godin, J. Santandrea, A. Caron, S. K. Collins, Org. Lett., 2020, 22, 5905-5909.

DOI: 10.1021/acs.orglett.0c02004

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Abstract

A mild, rapid, and selective copper-catalyzed Csp-S cross-coupling of thiols and bromoalkynes provides a broad range of alkynyl sulfides, including difficult-to-access bis-heteroatom-functionalized (S,S-, S,P-, and S,N-) alkynes.

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Key Words

alkynyl sulfides

ID: J54-Y2020