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Imine Amidation Catalyzed by a Chiral VAPOL Calcium Phosphate

Rui Cao and Jon C. Antilla*

*Institute for Molecular Design and Synthesis, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China, Email:

R. Cao, J. C. Antilla, Org. Lett., 2020, 22, 5958-5962.

DOI: 10.1021/acs.orglett.0c02048

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VAPOL metal phosphates are superior catalysts for imine amidation reactions to produce chiral N,N'-aminal products in high yields and with excellent ee values. Upon optimization, a wide substrate scope, low catalyst loading, and mild conditions are achieved.

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Key Words


ID: J54-Y2020