Imine Amidation Catalyzed by a Chiral VAPOL Calcium Phosphate
Rui Cao and Jon C. Antilla*
*Institute for Molecular Design and Synthesis, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China, Email: jantillatju.edu.cn
R. Cao, J. C. Antilla, Org. Lett., 2020, 22, 5958-5962.
see article for more reactions
VAPOL metal phosphates are superior catalysts for imine amidation reactions to produce chiral N,N'-aminal products in high yields and with excellent ee values. Upon optimization, a wide substrate scope, low catalyst loading, and mild conditions are achieved.
see article for more examples