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Brønsted Acid Catalyzed Cyclization of Aminodiazoesters with Aldehydes to 3-Carboxylate-N-Heterocycles

Yang Jiao, Anrong Chen, Bangkui Yu and Hanmin Huang*

*Department of Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. China, Email: hanminustc.edu.cn

Y. Jiao, A. Chen, B. Yu, H. Huang, Org. Lett., 2020, 22, 6031-6034.

DOI: 10.1021/acs.orglett.0c02125


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Abstract

A Brønsted acid catalyzed cyclization of aminodiazoesters with aldehydes provides a wide range of 5 to 7-membered 3-carboxylate-N-heterocycles. This reaction offers broad substrate scope and functional group compatibility.

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Key Words

2-pyrrolines


ID: J54-Y2020