Direct Synthesis of Mono-α-arylated Ketones from Alcohols and Olefins via Ni-Catalyzed Oxidative Cross-Coupling
Peng-Fei Yang and Wei Shu*
*Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, Guangdong, P. R. China,
Email: shuw
sustech.edu.cn
P.-F. Yang, W. Shu, Org. Lett., 2020, 22, 6203-6208.
DOI: 10.1021/acs.orglett.0c02340
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Abstract
A Ni-catalyzed dehydrogenative cross-coupling reaction cascade between readily available alcohols and olefins enables a direct synthesis of α-arylated ketones. This cost-effective method provides monoarylated ketones in good yields with exclusive selectivity without using any advanced synthetic intermediates.
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preligand
proposed mechanism
Key Words
ID: J54-Y2020
