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Designing a Planar Chiral Rhodium Indenyl Catalyst for Regio- and Enantioselective Allylic C-H Amidation

Caitlin M. B. Farr, Amaan M. Kazerouni, Bohyun Park, Christopher D. Poff, Joonghee Won, Kimberly R. Sharp, Mu-Hyun Baik* and Simon B. Blakey*

*Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea; Emory University, Atlanta, Georgia 30322, United States, Email:,

C. M. B. Farr, A. M. Kazerouni, B. Park, C. D. Poff, J. Won, K. R. Sharp, M.-H. Baik, S. B. Blakey, J. Am. Chem. Soc., 2020, 142, 13996-14004.

DOI: 10.1021/jacs.0c07305

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A planar chiral indenyl rhodium complex for enantioselective C-H functionalization catalysis is capable of catalyzing an asymmetric allylic C-H amidation of unactivated olefins, delivering a wide range of high-value enantioenriched allylic amide products in good yields with excellent regio- and enantioselectivity.

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Key Words

allylic amines, amides

ID: J48-Y2020