Asymmetric Transfer Hydrogenation of Unhindered and Non-Electron-Rich 1-Aryl Dihydroisoquinolines with High Enantioselectivity
Jonathan Barrios-Rivera, Yingjian Xu* and Martin Wills*
*GoldenKeys High-tech Materials Co., Ltd., Guian 550025, China; The University of Warwick, Coventry CV4 7AL, United Kingdom,
Email: goldenkeys9996thegoldenkeys.com.cn, m.wills
warwick.ac.uk
J. Barrios-Rivera, Y. Xu, Martin Wills, Org. Lett., 2020, 22, 6283-6287.
DOI: 10.1021/acs.orglett.0c02034
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Abstract
Arene/Ru/TsDPEN complexes bearing a heterocyclic group catalyze the asymmetric transfer hydrogenation (ATH) of 1-aryl dihydroisoquinolines (DHIQs) to provide tetrahydroisoquinolines of high enantiomeric excess.
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Key Words
tetrahydroisoquinolines, formic acid
ID: J54-Y2020