Photocatalytic Intramolecular C-H Amination Using N-Oxyureas as Nitrene Precursors
Ryan A. Ivanovich, Dilan E. Polat and André M. Beauchemin*
*Centre for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada, Email: abeaucheuottawa.ca
R. A. Ivanovich, D. E. Polat, A. M. Beauchemin, Org. Lett., 2020, 22, 6360-6364.
DOI: 10.1021/acs.orglett.0c02200 (free Supporting Information)
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The combined use of photocatalysis with careful engineering of the substrate enables C-H amination forming imidazolidinones and related nitrogen heterocycles from readily accessible hydroxylamine precursors. Preliminary mechanistic results are consistent with the formation of free carbamoyl triplet nitrenes as reactive intermediates.
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