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Nickel(II)-Catalyzed Borylation of Alkenyl Methyl Ethers via C-O Bond Cleavage

Xiaodong Qiu*, Yangyang Li, Li Zhou, Peishan Chen, Fan Li, Yanan Zhang and Yong Ling*

*School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, China, Email: qiuxiaodongntu.edu.cn, lyyy111sina.com

X. Qiu, Y. Li, L. Zhou, P. Chen, F. Li, Y. Zhang, Y. Ling, Org. Lett., 2020, 22, 6424-6428.

DOI: 10.1021/acs.orglett.0c02236


Abstract

Ni(II) catalyzes a borylation of conjugated alkenyl methyl ethers with B2pin2. Both E/Z isomers of alkenyl ethers are converted into (E)-alkenyl boronic esters. This chemoselective method tolerates aryl ether, ester, amide, and thioether groups.

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Key Words

alkenylboronates


ID: J54-Y2020