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General Synthesis of Tri-Carbo-Substituted N2-Aryl-1,2,3-triazoles via Cu-Catalyzed Annulation of Azirines with Aryldiazonium Salts

Fang-Fang Feng, Jun-Kuan Li, Xuan-Yu Liu, Fa-Guang Zhang, Chi Wai Cheung* and Jun-An Ma*

*Department of Chemistry, Tianjin University, Tianjin 300072, P. R. of China, Email:,

F.-F. Feng, J.-K. Li, X.-Y. Liu, F.-G. Zhang, C. W. Cheung, J.-A. Ma, J. Org. Chem., 2020, 85, 10872-10883.

DOI: 10.1021/acs.joc.0c01433 (free Supporting Information)

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A Cu-catalyzed annulation reaction of azirines and aryldiazonium salts provides fully substituted N2-aryl-1,2,3-triazoles. This regiospecific method allows access to a broad spectrum of products substituted with diverse aryl and alkyl moieties.

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proposed mechanism

Key Words


ID: J42-Y2020