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Regiodivergent Hydroborative Ring Opening of Epoxides via Selective C-O Bond Activation

Marc Magre, Eva Paffenholz, Bholanath Maity, Luigi Cavallo* and Magnus Rueping*

*KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia, Email:,

M. Magre, E. Paffenholz, B. Maity, L. Cavallo, M. Rueping, J. Am. Chem. Soc., 2020, 142, 14286-14294.

DOI: 10.1021/jacs.0c05917

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A readily available magnesium catalyst achieves a selective hydroboration of a wide range of epoxides and oxetanes yielding secondary and tertiary alcohols in excellent yields and regioselectivities.

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Key Words

cleavage of ethers, reduction of epoxides, pinacolborane

ID: J48-Y2020