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Dehydroxylative Fluorination of Tertiary Alcohols

Wei Zhang, Yu-Cheng Gu, Jin-Hong Lin* and Ji-Chang Xiao*

*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China, Email:,

W. Zhang, Y.-C. Gu, J.-H. Lin, J.-C. Xiao, Org. Lett., 2020, 22, 6642-6646.

DOI: 10.1021/acs.orglett.0c02438


Activation of a hydroxyl group by a Ph2PCH2CH2PPh2/ICH2CH2I system enables an efficient dehydroxylative fluorination of tertiary alcohols with Selectfluor. The reaction occurs rapidly to give the desired products in good yields.

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proposed mechanism

Key Words

Fluorination, Selectfluor

ID: J54-Y2020