Direct Synthesis of Enones by Visible-Light-Promoted Oxygenation of Trisubstituted Olefins Using Molecular Oxygen
Shinji Harada*, Daiki Matsuda, Takahiro Morikawa, Atsushi Nishida
*Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 2608675, Japan, Email: s.haradafaculty.chiba-u.jp
S. Harada, D. Matsuda, T. Morikawa, A. Nishida, Synlett, 2020, 31, 1372-1377.
see article for more reactions
A one-step reaction of trisubstituted olefins provides enones in good yields with high regioselectivity under visible-light irradiation in the presence of molecular oxygen and a photocatalyst. The reaction tolerates oxygen- and nitrogen-containing functional groups, heteroaromatic rings, and cyclopropanes.
see article for more examples
oxygen, oxygenation, photochemistry, ruthenium catalysis, alkenes