Regio- and Enantioselective Allylic Alkylation of Terminal Alkynes by Synergistic Rh/Cu Catalysis
Wen-Yu Huang, Chun-Hua Lu, Samir Ghorai, Bing Li and Changkun Li*
*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China,
Email: chkli
sjtu.edu.cn
W.-Y. Huang, C.-H. Lu, S. Ghorai, B. Li, C. Li, J. Am. Chem. Soc., 2020, 142, 15276-15281.
DOI: 10.1021/jacs.0c08283
see article for more reactions
Abstract
A highly enantioselective Sonogashira type synergistic Rh and Cu catalysis of readily available terminal alkynes and racemic allylic carbonates provides branched 1,4-enynes under neutral conditions. Aliphatic and aromatic terminal alkynes with various functional groups could be used directly.
see article for more examples
Key Words
ID: J48-Y2020
