Alkyltriflones in the Ramberg-Bäcklund Reaction: An Efficient and Modular Synthesis of gem-Difluoroalkenes
Yuuki Maekawa, Masakazu Nambo*, Daisuke Yokogawa and Cathleen M. Crudden*
*Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya, Japan, Email: mnamboitbm.nagoya-u.ac.jp, cruddencchem.queensu.ca
Y. Maekawa, M. Nambo, D. Yokogawa, C. M. Crudden, J. Am. Chem. Soc., 2020, 142, 15667-15672.
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The Ramberg-Bäcklund reaction of alkyl triflones provides structurally diverse, fully substituted gem-difluoroalkenes that are difficult to prepare by treatment with specific Grignard reagents. The Grignard reagent serves both as a base to remove the α-proton and as a Lewis acid to assist C-F bond activation.
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Ramberg-Bäcklund Reaction, Fluoroalkenes